Proven Key to Long Life
According to US scientists, boosting the body’s levels of natural antioxidants could be the key to a long life. Numerous studies in simple organisms, such as yeast, worms, and flies have supported this theory by showing that enhancing production of natural antioxidants can extend life. However, proof that antioxidants can slow the aging way in mammals has been less convincing. Of Genes and Mice To investigate whether increased concentrations of natural antioxidants give mammals longer lives, Peter S. Rabinovitch of the University of Washington in Seattle and his colleagues came up with a study involving genetically engineered mice. The mice were purposely engineered to over-express a gene responsible for making the antioxidant called catalase. Normally, the catalase that a cell makes goes directly into organelles known as peroxisomes. What Rabinovitch and his colleagues did was to design a genetic manipulative way so that in some of the mice, the extra catalase went into its common location while in the rest of the mice, the extra catalase went into the cell nucleus. A third group of the engineered mice directed the enzyme into the mitochondria, the cell’s energy-producing organelles. As a side effect of converting food into energy, mitochondria produce the bulk of an organism’s free radicals. The study showed no difference in life span between common animals and those engineered to keep the extra catalase in the nucleus. And those mice engineered to direct catalase to its normal place, in peroxisomes, showed only a modest increase in life span. Rabinovitch and his colleagues, however, found that animals that guided catalase to mitochondria lived significantly longer than common mice. In fact, the way seemed to contribute about 5 months to their common 3-year life span. When the researchers dissected some of the mice, they found early signs of age-associated disease, such as cataracts and heart disease, at later ages in the long-lived, engineered mice than in the others. This showed that mice engineered to produce high levels of an antioxidant enzyme have a life span that is 20% longer than those of common mice. Results of the study also showed that they had less heart and other age-related diseases. If the same is true among humans, then it’s possible that people could survive beyond 100 years. The Power of Reishi In a thoroughly dissimilar study, Reishi, a Chinese mushroom (also known as Ganoderma lucidum, Lingzhi, or Ling Zhi), was featured to cause a significant post-ingestion increase in plasma antioxidant capacity with peak response at 90 minutes. This means that Reishi can cause increase in urine antioxidant capacity in just 3 hours. Published in 2004 by the International Journal of Food Sciences and Nutrition, the outcomes of the study indicate that Reishi consumption causes an acute increase in plasma antioxidant capacity. Reishi is a powerful antioxidant. In another laboratory study, Reishi significantly elevated the free radical scavenging capability of blood and was so strong that even after the Reishi extract was absorbed and metabolized the scavenging effect still continued. Dr. Vladimir Kupin of the Cancer Research Centre in Moscow found a compound in Reishi called GLB 7 which served as the major proponent in decreasing the production of oxygen free radicals. This makes Reishi more effective as a free radical scavenger than isolated refined compounds. A laboratory study with fruit flies also showed just how powerful an antioxidant Reishi is. The flies, which have a very similar genetic make up to humans, were used in experiments to prove that Reishi significantly lengthened the life span of those that had been fed Reishi compared to controls. |
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